Printen
Tomaten tegen alvleesklierkanker.*
Het regelmatig eten van tomaten blijkt de kans op
alvleesklierkanker wel met 30% te reduceren. Hiervoor verantwoordelijk is vooral
de lycopeen in de tomaten.
Dietary
Intake of Lycopene Is Associated with Reduced Pancreatic Cancer Risk1
André
Nkondjock*,
,
Parviz Ghadirian*,**,2, Kenneth C. Johnson
,
Daniel Krewski
and the Canadian Cancer Registries Epidemiology Research Group
*
Epidemiology Research Unit, Research Centre, Centre hospitalier de l’Université
de Montréal (CHUM)-Hôtel-Dieu;
McLaughlin
Centre for Population Health Risk Assessment, Institute of Population Health,
University of Ottawa, Ottawa, ON, Canada; ** Department of Nutrition,
Faculty of Medicine, University of Montreal, Montreal, QC, Canada; and
Surveillance
and Risk Assessment Division, Centre for Chronic Disease Prevention and Control,
Population and Public Health Branch, Health Canada, Ottawa, Canada
2To
whom correspondence should be addressed. E-mail:
parviz.ghadirian@umontreal.ca.
Although fruits and vegetables have been implicated in the etiology of pancreatic cancer, the role of phytochemicals in these food groups has received little attention to date. In this study, we investigated the possible association between dietary carotenoids and pancreatic cancer risk. A case-control study of 462 histologically confirmed pancreatic cancer cases and 4721 population-based controls in 8 Canadian provinces took place between 1994 and 1997. Dietary intake was assessed by a self-administered FFQ. Unconditional logistic regression was used to assess associations between specific and total carotenoid intakes and the risk of pancreatic cancer. All tests of statistical significance were 2-sided. After adjustment for age, province, BMI, smoking, educational attainment, dietary folate, and total energy intake, lycopene, provided mainly by tomatoes, was associated with a 31% reduction in pancreatic cancer risk among men [odds ratio (OR) = 0.69; 95% CI: 0.46–0.96; P = 0.026 for trend] when comparing the highest and lowest quartiles of intake. Both ß-carotene (OR = 0.57; 95% CI: 0.32–0.99; P = 0.016 for trend) and total carotenoids (OR = 0.58; 95% CI: 0.34–1.00; P = 0.02 for trend) were associated with a significantly reduced risk among those who never smoked. The results of this study suggest that a diet rich in tomatoes and tomato-based products with high lycopene content may help reduce pancreatic cancer risk. (maart 2005)