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De rol van Glutathion en kanker.*
In een uitgave van Cell Bochemistry
and Function wordt dieper ingegaan op de beschermende rol van Glutathion en
kanker.
The role of glutathione in
cancer.
Balendiran GK, Dabur R, Fraser D.
Division of Immunology, Beckman Research Institute of the City of Hope, Duarte,
CA, USA.
Glutathione is an abundant natural tripeptide found within almost all cells.
Glutathione is highly reactive and is often found conjugated to other molecules
via its sulfhydryl moiety. It instils several vital roles within a cell
including antioxidation, maintenance of the redox state, modulation of the
immune response and detoxification of xenobiotics. With respect to cancer,
glutathione metabolism is able to play both protective and pathogenic roles. It
is crucial in the removal and detoxification of carcinogens, and alterations in
this pathway, can have a profound effect on cell survival. However, by
conferring resistance to a number of chemotherapeutic drugs, elevated levels of
glutathione in tumour cells are able to protect such cells in bone marrow,
breast, colon, larynx and lung cancers. Here we present a number of studies
investigating the role of glutathione in promoting cancer, impeding
chemotherapy, and the use of glutathione modulation to enhance anti-neoplastic
therapy. Copyright 2004 John Wiley & Sons, Ltd. PMID: 15386533 [PubMed - as
supplied by publisher] (aug. 2004)