Printen
Foliumzuur tegen acute hart- en vaatproblemen.*
Uit een Finse studie onder ruim 1000 mannen van 46 tot 64
jaar, die nog nooit hartproblemen gehad hadden blijkt dat die mannen met de
hoogste bloedwaarden aan foliumzuur wel 65% minder kans hadden op een acuut
hart- en vaatprobleem. Interressant was dat er geen relatie bleek te zijn
tussen bloedwaarden homocysteïne en de kans op hart- en vaatproblemen.
Serum folate and homocysteine
and the incidence of acute coronary events: the Kuopio Ischaemic Heart Disease
Risk Factor Study1,2,3
Sari Voutilainen, Jyrki K Virtanen, Tiina H Rissanen,
Georg Alfthan, Jari Laukkanen, Kristiina Nyyssönen, Jaakko Mursu, Veli-Pekka
Valkonen, Tomi-Pekka Tuomainen, George A Kaplan and Jukka T Salonen
1 From the Research Institute of Public Health (SV, JKV,
JL, KN, JM, V-PV, T-PT, and JTS) and the Department of Public Health and
General Practice (THR), University of Kuopio, Kuopio, Finland; the Biomarker
Laboratory, National Public Health Institute, Helsinki (GA); the Department of
Epidemiology, School of Public Health, University of Michigan, Ann Arbor
(GAK); and the Inner Savo Health Centre, Suonenjoki, Finland (JTS)
Background: Several, but not all, prospective studies have shown
that low folate intakes, low circulating folate concentrations, or
high plasma total homocysteine (tHcy) concentrations are associated
with an increased risk of coronary artery disease (CAD).
Objective: We examined the relations of both serum folate and
serum tHcy concentrations with acute coronary events in middle-aged
men from eastern Finland who had no CAD at baseline.
Design: In a population-based prospective cohort study, 1027
men aged 46–64 y were examined in 1991–1993 as part of
the Kuopio Ischaemic Heart Disease Risk Factor Study. During an
average follow-up of 7.7 y (7900 person-years of follow-up), 114
acute coronary events were observed in 61 men who had no previous
history of CAD (n = 810).
Results: In a Cox model, compared with men whose serum folate
concentrations were in the lowest tertile, those whose concentrations
were in the highest tertile had a risk factor–adjusted relative
risk of acute coronary events of 0.35 (95% CI: 0.17, 0.73; P
= 0.005). Serum tHcy concentrations were not significantly associated
with the risk of acute coronary events (for the highest tertile
compared with the lowest, adjusted relative risk = 1.03; 95% CI:
0.57, 1.87; P = 0.932).
Conclusions: The results of this prospective cohort study do not support the hypothesis that a high circulating tHcy concentration is a risk factor for acute coronary events in a male population free of prior heart disease. However, they do suggest that moderate-to-high serum folate concentrations are associated with a greatly reduced incidence of acute coronary events. (juli 2004)