Vitamine E effectief bij chemotherapie.*

A study was published in the Journal of Clinical Oncology. In the study forty seven patients with cancer were scheduled to receive cisplatin chemotherapy, which is a very powerful and highly toxic agent. These patients were randomly assigned to receive 300 mg vitamin E supplementation daily during the cisplatin therapy with a second group receiving the chemotherapy alone. Vitamin E was administered orally before cisplatin chemotherapy and continued for three months after the suspension of treatment. Twenty-seven patients completed six cycles of chemotherapy; thirteen patients in the group receiving vitamin E and fourteen patients not receiving the vitamin. The incidence of neurotoxicity in the vitamin E treated group was approximately 30% as compared to 85% neuro-toxicity in the group that received the chemotherapy without the vitamin E. Even in this small clinical trial, the statistical significance reached .01 (meaning that there was only a 1% likelihood that this happened by chance with a 99% likelihood that the results were accurate). As a neurologist, unfortunately I see many patients with neurologic side effects from chemotherapy. I will surely be recommending vitamin E to my oncology colleagues to prescribe to all of their cancer patients. (2003)

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