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Plant extract could lead to new drug development for H1N1
Scientists in China have discovered that roots of a plant used a century ago during the great Spanish influenza pandemic contains substances with powerful effects in laboratory experiments in killing the H1N1 swine flu virus that now threatens the world. The plant has a pleasant onion-like taste when cooked, but when raw it has sap so foul-smelling that some call it the "Dung of the Devil" plant. Their report is scheduled for the Sept. 25 issue of ACS' Journal of Natural Products, a monthly publication.
In the study, Fang-Rong Chang and Yang-Chang Wu and colleagues note that the plant, Ferula assa-foetida, grows mainly in Iran, Afghanistan and mainland China. People used it as a possible remedy during the1918 Spanish flu pandemic that killed between 20 to 100 million people. Until now, however, nobody had determined whether the plant does produce natural antiviral compounds.
Chang and Wu identified a group of chemical compounds in extracts of the plant that showed greater potency against influenza A (H1N1) than a prescription antiviral drug available for the flu. "Overall, the present study has determined that sesquiterpene coumarins from F. assa-foetida may serve as promising lead components for new drug development against influenza A (H1N1) viral infection," the authors write.
Source: American Chemical Society
Two new sesquiterpene coumarins, designated 5′-acetoxy-8′-hydroxyumbelliprenin (1) and 10′R-acetoxy-11′-hydroxyumbelliprenin (2), and a new diterpene, 15-hydroxy-6-en-dehydroabietic acid (3), along with 27 known compounds, were isolated from a CHCl3-soluble extract of Ferula assa-foetida through bioassay-guided fractionation. The structures of the new metabolites 1−3 were identified by spectroscopic data interpretation and by the Mosher ester method. Compounds 4 and 6−13 showed greater potency against influenza A virus (H1N1) (IC50 0.26−0.86 μg/mL) than amantadine (IC50 0.92 μg/mL), and 11 exhibited the best potency (IC50 0.51, 2.6, and 3.4 μg/mL) of these compounds against the HepG2, Hep3B, and MCF-7 cancer cell lines, respectively. (September 2009)
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