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The link between aspartame and brain
tumors: What the FDA never told you about artificial sweeteners
On September 30, 1980, a public Board of Inquiry advised against the approval of aspartame, stating: "The Board has not been presented with proof of a reasonable certainty that aspartame (NutraSweet) is safe for use as a food additive under its intended conditions of use." In 1981, however, the FDA approved aspartame for consumer use based on studies that seem tainted by heavy financial interest in its approval. To many medical practitioners and consumer interest groups, the approval was a gross betrayal of public trust. "To think that there is even a reasonable doubt that aspartame can induce brain tumors in the American population is frightening. And to think that the FDA has lulled them into a false sense of security is a monumental crime," writes Dr. Russell L. Blaylock in Excitotoxins. In 2005, twenty-five years after the initial Board of Inquiry's caution against approval, numerous adults and children consume aspartame-sweetened products on a daily basis, despite reservations regarding its safety. Drinking Formaldehyde The next time you pop open a can of diet soda, pause for a moment to consider what exactly you're drinking. As the aspartame gets broken down in your digestive tract, a metabolic by-product called DKP appears. According to Dr. Blaylock, when your stomach processes DKP, it produces a compound very similar to N-nitrosourea, a powerful brain tumor-causing chemical. In addition, aspartame contains methanol, which the body breaks down into formic acid and formaldehyde. Formaldehyde is one of the main substances pumped into a dead body during the embalming process.Now, when I'm dead, the morticians can pump formaldehyde into my body. Before then, however, I don't want to be pumped full of any chemical used in the embalming process, and I'm sure you don't, either. According to Dr. Blaylock, formaldehyde accumulates near DNA and causes serious damage. "Drinking even one diet cola a day can cause formaldehyde buildup in cells, so that the amount of the toxin increases daily," he writes in Health and Nutrition Secrets. "Urban myths" of the aspartame industry You can visit the website for Equal, which says that aspartame-induced tumors, migraines, seizures and nervous system disorders are just "urban myths." If you believe that, you probably also believe the aspartame industry's argument that the studies that resulted in the condemnation of their products were based on lab rats instead of humans. Just take note, however, that "spontaneous brain tumors in laboratory rats are extremely rare," according to Dr. H.J. Roberts in Aspartame (NutraSweet): Is It Safe?. So before you believe what the manufacturers of aspartame products would like to tell you, consider first the fact that for extensively-studied, generic laboratory rats, "brain tumors are extremely rare before age one and one-half," according to Dr. Blaylock. Afterward, compare that observation to study results cited by Dr. Blaylock that indicate "aspartame-fed rats developed two tumors by 60 weeks of age and five tumors by 70 weeks." Now, do you still believe it's an "urban myth?"In light of the truth regarding the safety of aspartame products, it is ironic that consumers often turn to no-calorie diet products because of concern for their health, especially in regard to obesity. The aspartame industry promises consumers a reduction in calories without having to drastically change their diet. Unfortunately, misinformed consumers believe this. To the more informed readers out there: Don't beguile yourselves chasing false promises. You can lose weight by maintaining a healthy lifestyle through exercise and good food choices. The website can provide you with information you need to start making these changes. Additionally, if you want a truly natural way to sweeten your foods and drinks, try stevia. You can learn more about stevia at NewsTarget's stevia archive. The right information is available to you, but it's up to you to discern the good from the bad and make healthy lifestyle choices. The experts speak on aspartame and brain tumors: "September 30, 1980: A public Board of Inquiry advises against aspartame" A Public Board of Inquiry (PBOI) advised against the approval of
aspartame on September 30, 1980 pending further testing relative to
induced brain tumors. It asserted: "The Board has not been
presented with proof of a reasonable certainty that aspartame (nutrasweet)
is safe for use as a food additive under its intended conditions of
use." "Results of studies prior to the FDA's approval of aspartame" …. The fact that 320 aspartame fed rats developed six brain
tumors by seventy-six weeks indicates an "incredible and
unprecedented'' occurrence. .. This particularly nasty substance should have never even been
approved for human use. In fact, had it not been for some fancy
footwork by those in power in the FDA, it never would have. Early
experiments using low, medium and high doses with aspartame all
found dramatic tumor increases in test animals. These included brain,
pancreas, and breast tumors… Importantly, brain tumors are extremely rare before age one and
one-half in the rat. So in truth the incidence of spontaneously
occurring brain tumors would be even less than cited above. Yet, the
aspartame fed rats developed two tumors by sixty weeks of age and
five tumors by seventy weeks. Dr. M. Adrian Gross, a respected FDA scientist-pathologist,
listed dozens of "serious deficiencies" by a manufacturer
and its representatives concerning the prelicensing evaluation of
aspartame in animal studies . . . the most serious pertaining to
brain tumors. When Dr. John Olney pointed out these findings to the FDA "aspartame
Board of Inquiry" he was told that the high incidence of tumors
was the result of spontaneous development of brain tumors in rats.
.. He reviewed the incidence of spontaneously occurring brain tumors
in rats and found that out of seven studies using a total of 59,000
rats, only 0.08% developed brain tumors—the aspartame fed rats had
a forty-seven fold higher incidence. But to be fair, he even
accepted G.D. Searle's references for spontaneously developing brain
tumors in rats and arrives at a figure of 0.15%. This was still a
twenty-five fold higher incidence in the aspartame fed rats than in
the controls. There has been virtually no outcry by health professionals, the
FDA or the public over the approval of aspartame-containing products
for human consumption when pre-licensing animal studies showed brain
and uterine tumors in rats (Cornell 1984). … The study divided the rats into those exposed to low doses of
aspartame and those exposed to a high dose. In the low dose group
five of the rats developed brain tumors for and incidence of 3.13%.
In the high dose group, seven developed brain tumors (4.38%). This
indicates a dose related incidence of brain tumors. The higher the
dose of aspartame, the more brain tumors were induced. "The FDA approved aspartame in 1981: Why?" It is interesting to note that the first experiments done to test
the safety of aspartame before its final approval in 1981 disclosed
a high incidence of brain tumors in the animals fed nutrasweet®
.4S4 In fact, this study was done by the manufacturer of nutrasweet®,
G.D. Searle. In this study 320 rats were fed aspartame and 120 rats
were fed a normal diet and used as controls. The study lasted two
years. At the end of the study twelve of the aspartame fed rats had
developed brain tumors (astrocytomas), while none of the control
rats had. This represented a 3.75% incidence of brain tumors in the
rats fed aspartame, which was twenty-five times higher than the
incidence of spontaneous brain tumors developing in rats (0.15%) … Despite concerns over the safety of this new sweetener, including
brain tumor induction in experimental animals, seizures,
precipitation of headaches,
and an adverse effect on the developing brain, the FDA approved its
use as an artificial sweetener. Sales began to grow immediately. The
nutrasweet® company spent over 60 million dollars on advertising
alone during its first three years. …. What is ironic is that the FDA would accept studies from a
company with an obvious heavy financial interest in having aspartame
approved. But even more amazing is that they would depend on this
same company to provide studies that they, FDA, knew beforehand were
highly questionable and possibly fraudulent upon which they would
make such an important public safety decision. "In view of all these indications that the cancer-causing
potential of aspartame is a matter that has been established way
beyond any reasonable doubt, one can ask: 'What is the reason for
the apparent refusal by the FDA to invoke for this food additive the
Delaney Amendment to the Food, Drug, and Cosmetic Act?' " …. To think that there is even a reasonable doubt that
aspartame can induce brain tumors in the American population is
frightening. And to think that the FDA has lulled them into a false
sense of security is a monumental crime. "How aspartame possibly causes tumors" But the story gets even more interesting. Dr. Olney hypothesized
that one possible cause of the tumor induction was a by-product of
aspartame metabolism
called diketopiperazine (DKP). When nitrosated by the gut it
produces a compound closely resembling a powerful brain tumor
causing chemical— N-nitrosourea. Several possibilities explain the high rate of cancer
in these animals. One is that aspartame breaks down in the body into
a substance called diketopiperizine or DKP, which chemically closely
resembles a group of cancer-causing chemicals. aspartame also
contains methanol, which breaks down in the body into formaldehyde
and formic acid. Formaldehyde had been shown to accumulate near DNA,
causing serious damage that is accumulative. That means that
drinking even one diet cola a day can cause formaldehyde buildup in
cells, so that the amount of the toxin increases daily. "Results and accuracy of animal studies" …. The study showed that in 320 nutrasweet-fed rats there were
12 brain tumors whereas in a group of concurrent control rats which
were not exposed to nutrasweet, there were no brain tumors. Being a
neuropathologist, I know that spontaneous brain tumors in laboratory
rats are extremely rare. The archival literature documents an
incidence not exceeding 0.6%. Since the above incidence in
nutrasweet-fed rats is 3.75%, this suggests that nutrasweet may
cause brain tumors and certainly suggests the need for additional
in-depth research to rule out that possibility . . . Male and female Sprague-Dawley rats fed aspartame in the diet at
various levels for up to 2 years were observed for the incidence of
brain tumors (G. D. Searle and Co., 1973b). After the study was
completed, the FDA appointed an independent board of inquiry to
review the data. The board concluded that aspartame was a possible
carcinogen, based on three of the study's findings: The incidence of
brain neoplasms in aspartame-fed rats was greater than that in
controls, … …. Dr. Lampert personally examined the microscopic slides
pertaining to the brain tumor studies and told me a year or so after
the PBOI report was completed that he had been surprised at the
large size of the brain tumors in the nutrasweet-fed rats." … brain tumors in all age groups jumped by greater than ten
percent….Dr. H. J. Roberts, who has written an excellent book on
the dangers of aspartame, has collected some evidence that one
particular type of brain tumor may be associated with nutrasweet®.488
This tumor is known as a primary lymphoma of the brain. It is a
particularly nasty tumor with a high mortality rate. Other observations in both animals studies and aspartame reactors
should evoke concern about the potential tumor-causing role of
aspartame-containing products. "Should you consume aspartame?" …and aspar-tame (nutrasweet) …. Some experts suspect them of
promoting cancer and having toxic effects on the nervous system. You
are much better off eating moderate amounts of sugar
than any of these unnatural compounds. ACTIONS TO aspartame-CONTAINING products may pose potential
public health threats. This chapter will address some of these
possibilities—including aspartame-related accidents, suicide,
criminality, cancer, and excessive diagnostic radiation. …. Avoid all nutrasweet®, Equal®, and aspartame in any form.
There is evidence that this sweetener can impair your genetic
structure, increase cancer risk and can be toxic to your nervous
system. "I would view the Acceptable Daily Intake (ADI) set by the
FDA for aspartame (50 mg/kg body weight/ day) as totally unwarranted
and extremely high in that it can be associated with completely
unacceptable risks as far as the induction of such (brain) tumors is
concerned. It is clear that risks of this magnitude for what the FDA
regards as a 'safe' level of exposure to aspartame represent an
outright calamity or disaster." (Italics supplied) and extremely high in that it can be associated with completely
unacceptable risks as far as the induction of such (brain) tumors is
concerned- It is clear that risks of this magnitude for what the FDA
regards as a '"safe'" level of exposure to aspartame
represents an outright calamity or disaster.23 Some primary brain lymphomas are associated with immune
depression seen with AIDS. One would expect these to increase. But
there is also a dramatic increase in these previously rare tumors in
individuals without AIDS.489 Some have suggested that the recent
increase in brain tumors merely reflects better diagnostic methods.
But a recent study found this not to be true; the increase is real.490
Dr. Roberts feels that an association with the tremendous rise in
the use of aspartame products in the last decade may hold the answer. A 57-year-old executive developed severe insomnia. His physician
attributed it to "jet lag" because of his frequent travels
abroad. He was consuming 10 to 12 cans of an aspartame cola and 4 to
6 packets of an aspartame powdered sweetener daily. A tranquilizer (Halcion®)
was prescribed—but only intensified the insomnia. He was referred
to a psychiatrist for possible depression . . . then to an
endocrinologist for a possible brain tumor. The psychiatrist treated
him for three years, during which time he was ".. becoming
significantly more moody, nervous, and experiencing memory loss and
speech difficulties (frustrating to me, but really not that
noticeable to others)." Low doses of the antidepressant drug
Tofranil® triggered "a near panic attack." within two
weeks after discontinuing aspartame products, he was markedly
improved. ... Phenylalanine is the toxic component seen in the childhood
disorder called phenylketonuria or PKU. In this disorder,
phenylalanine accumulates in the blood and hence brain, in very high
concentrations. Carriers for the gene develop blood levels of
phenylalanine twice as high as those of normal people, when
consuming an equal amount of aspartame. … In addition, the
metabolic breakdown of aspartame yields about a dozen toxic
compounds, some of which have been associated with cancer induction
and alteration of brain
function. The fewer of these toxins and foreign chemicals you
expose your unborn child to the better. This also applies to
newborns, toddlers, adolescents and adults as well. All of the
toxins produced by ingesting aspartame must be detoxified and this
puts a strain on the body's ability to cope. A 30-year-old woman consumed an average of five to six cups or
glasses of aspartame beverages daily for 17 months. Ringing and pain
in both ears, dizziness, and a severe headache began after the tenth
month. Audiometric studies revealed considerable loss of hearing in
the left ear. When brain tumor was ruled out by CT scan, the otology
and neurology consultants diagnosed her problem as Meniere's disease.
The patient herself, however, finally deduced that the aspartame
drinks caused these symptoms because she could predictably reproduce
them on rechallenge. I hope not, but ignoring the long-term problems seemingly
associated with use of aspartame-containing products might portend
another "thalidomide revolution". It is imperative that
researchers who are not influenced by producer-corporations gather
detailed data concerning the incidence rates of epilepsy,
visual problems, allergies, Parkinsonism, brain tumors and
Alzheimer's disease among aspartame consumers. The same applies to
other disorders—including the frequency of birth defects, seizures,
impaired intelligence and behavioral abnormalities among the
children of women who ingested aspartame products at conception and
during pregnancy. Many people believe that the real enemy among the sweeteners is
aspartame — several Web sites are devoted to attacking it (among
them holisticmed.com). It's been linked to everything from headaches,
multiple sclerosis, loss of brain function, epilepsy, chronic
fatigue syndrome, Parkinson's, Alzheimer's, brain tumors, lymphoma,
and lupus to diabetes itself. Some people may be sensitive to
aspartame, which most commonly causes headaches. … Another food additive to avoid is aspartame, also called
nutrasweet, …. More important, evidence now exists that aspartate
affects the nervous system and spinal cord, promoting brain neurons
to die, and thus leading to neurologic diseases, such as Parkinson's,
Alzheimer's, and Lou Gehrig's disease (amyotrophic lateral sclerosis).
It also damages the brains of infants and children, who then have a
higher that normal propensity for suffering neurologic diseases
later in their lives…. When the complainants stop using the product, the symptoms go
away, returning only when they resume use of aspartame or products
containing it. Many physicians
refer to these symptoms as "aspartame disease." Some
physicians and scientists believe it to be an underlying cause of
brain tumors, comas, and death. The manufacturer of aspartame and
the FDA deny any association between aspartame and these conditions. Printen |