Vitamine D en hart- en vaatziekten*
Volgens een Deense studie onder ruim 10.000 mensen, die 29 jaar gevolgd werden blijkt dat te weinig vitamine D de kans op hart- en vaatziekten en een vroegtijdige dood flink kan verhogen. Zij met de hoogste
bloedwaarden vitamine D (> 20 ng/ml) bleken 40%
minder kans te hebben op een hartziekte, 64% minder kans op een hartaanval, 57% minder kans op een vroegtijdige dood en 81% minder kans op een fatale hartziekte alles vergeleken met zij met de laagste bloedwaarden vitamine D.
25-Hydroxyvitamin D Levels and Risk of Ischemic Heart Disease, Myocardial Infarction, and Early Death
Population-Based Study and Meta-Analyses of 18 and 17 Studies
1. Peter Brøndum-Jacobsen, 2. Marianne Benn, 3. Gorm B. Jensen, 4. Børge G. Nordestgaard
+ Author Affiliations
1. From the Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark (P.B.-J., M.B., B.G.N.); Faculty of Health Sciences, University of Copenhagen, Denmark (P.B.-J., M.B., B.G.N.); and the Copenhagen City Heart Study, Bispebjerg Hospital, Copenhagen University Hospital, Denmark (G.B.J., B.G.N.).
1. Correspondence to Børge G. Nordestgaard, MD, DMSc, Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK-2730 Herlev, Denmark. E-mail Boerge.Nordestgaard@regionh.dk
Abstract
Objective—We tested the hypothesis that reduced plasma 25-hydroxyvitamin D associates with increased risk of ischemic heart disease, myocardial infarction, and early death.
Methods and Results—We measured baseline plasma 25-hydroxyvitamin D in 10 170 women and men from the Danish general population without vitamin D–fortified food. During 29 years of follow-up, 3100 persons developed ischemic heart disease, 1625 myocardial infarction, and 6747 died. Decreasing plasma 25-hydroxyvitamin D levels were associated with increasing risk of ischemic heart disease, myocardial infarction, and early death as a function of seasonally adjusted percentile categories (P for trend, 2×10−5–3×10–53). Comparing individuals with plasma 25-hydroxyvitamin D levels at the 1st to 4th percentile with individuals with levels at the 50th to 100th percentile, the multivariable adjusted risk was increased by 40% (95% CI, 14%–72%) for ischemic heart disease, by 64% (25%–114%) for myocardial infarction, by 57% (38%–78%) for early death, and by 81% (40%–135%) for fatal ischemic heart disease/myocardial infarction. In the meta-analyses of 18 and 17 studies, risk of ischemic heart disease and early death were increased by 39% (25%–54%) and 46% (31%–64%) for lowest versus highest quartile of 25-hydroxyvitamin D level.
Conclusion—We observed increasing risk of ischemic heart disease, myocardial infarction, and early death with decreasing plasma 25-hydroxyvitamin D levels. These findings were substantiated in meta-analyses.
(September 2012)
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