Citrusfruit
voor lager cholesterol.*
Uit een Koreaans-Isralisch onderzoek met ratten blijkt dat de in grapefruit en sinaasappelen volop aanwezige bioactieve stoffen zoals hesperidine en naringenine het cholesterol flink kunnen doen dalen. De voeding van de dieren werd aangevuld met deze bioactieve stoffen en na 30 dagen bleek dat de bloedwaarden aan cholesterol met 20-25% gedaald waren.
Effect
of hesperidin and naringin on the plasma lipid profile and plasma antioxidant
activity in rats fed a cholesterol-containing diet
Shela
Gorinstein 1 *,
Hanna Leontowicz
2, Maria
Leontowicz
2,
Ryszard Krzeminski
2,
Mikolaj Gralak
2, Zenon
Jastrzebski
3,
Yong-Seo Park
4,
Soon-Teck Jung
5,
Seong-Gook Kang
6, Simon
Trakhtenberg
7
1Department
of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew
University, Hadassah Medical School, Jerusalem, Israel
2Department of Physiological Sciences, Faculty of
Veterinary Medicine, Warsaw Agricultural University, Warsaw, Poland
3Department of Pharmacology, Institute of Public Health,
Warsaw, Poland
4Department of Horticultural Science, Mokpo National
University, Muan Jeonnam 534-729, Korea
5Department of Food Engineering, Mokpo National University,
Muan Jeonnam 534-729, Korea
6Food Industrial Technology Research Center, Mokpo National
University, Muan Jeonnam 534-729, Korea
7Kaplan University Medical Center, Rehovot, Israel
email:
Shela Gorinstein (gorin@cc.huji.ac.il)
*Correspondence to Shela Gorinstein, Department of Medicinal Chemistry and
Natural Products, School of Pharmacy, The Hebrew University, Hadassah Medical
School, Jerusalem, Israel
Funded
by:
Korean Ministry of Commerce, Industry and Energy
The
objective of this study was to compare the influence of hesperidin and naringin,
the main flavonones of orange and grapefruit, on plasma lipid profile and
antioxidant activity in rats fed a cholesterol-containing diet. Sixty male
Wistar rats were randomly divided into six groups of 10, named Control,
Hesperidin, Naringin, Chol, Chol/Hesperidin and Chol/Naringin. The Control group
was fed a basal diet (BD) and 1-2 mL of distilled water. To the BD of the other
five groups were added 0.1-0.2 mg of hesperidin dissolved in 1-2 mL of distilled
water (Hesperidin group), 0.46-0.92 mg of naringin in 1-2 mL of water (Naringin
group), 1% of non-oxidised cholesterol (NOC) and 1-2 mL of water (Chol), 1% of
NOC and 0.1-0.2 mg of hesperidin in 1-2 mL of water (Chol/Hesperidin), 1% of NOC
and 0.46-0.92 mg of naringin in 1-2 mL of water (Chol/Naringin). After 30 days
of the experiment it was found that the diets supplemented with hesperidin and
naringin increased the plasma antioxidant activity. In conclusion, diets
supplemented with hesperidin and naringin significantly hindered the increase in
plasma lipid levels caused by cholesterol feeding. Hesperidin and naringin,
bioactive compounds of citrus fruits, are powerful plasma lipid lowering and
plasma antioxidant activity increasing flavonones. Copyright © 2007 Society of
Chemical Industry