Mensen met diabetes leven 15 jaar korter*

Diabetici worden gemiddeld vijftien jaar eerder getroffen door hart- en vaatziekten dan andere mensen. Dat blijkt uit een studie in het vakblad The Lancet. Onderzoekers uit Toronto vergeleken de gezondheidsgegevens van 379.000 volwassen diabetespatiënten in de provincie Ontario met die van de overige 9 miljoen inwoners. Ze kwamen tot de bevinding dat mannen met diabetes al op 48 jaar een hoger risico lopen op hartinfarct en beroerte. Bij vrouwen zou dat vanaf 54 jaar het geval zijn. Diabetici moeten daarom veel sneller hun voorzorgen nemen, menen de onderzoekers. 

The Lancet 2006; 368:29-36

DOI:10.1016/S0140-6736(06)68967-8

Relation between age and cardiovascular disease in men and women with diabetes compared with non-diabetic people: a population-based retrospective cohort study

Dr Gillian L Booth MD, Moira K Kapral MD, Kinwah Fung MSc and  Jack V Tu MD

Summary

Background

Adults with diabetes are thought to have a high risk of cardiovascular disease (CVD), irrespective of their age. The main aim of this study was to find out the age at which people with diabetes develop a high risk of CVD, as defined by: an event rate equivalent to a 10-year risk of 20% or more; or an event rate equivalent to that associated with previous myocardial infarction.

Methods

We did a population-based retrospective cohort study using provincial health claims to identify all adults with (n=379 003) and (n=9 018 082) without diabetes mellitus living in Ontario, Canada, on April 1, 1994. Individuals were followed up to record CVD events until March 31, 2000.

Findings

The transition to a high-risk category occurred at a younger age for men and women with diabetes than for those without diabetes (mean difference 14·6 years). For the outcome of acute myocardial infarction (AMI), stroke, or death from any cause, diabetic men and women entered the high-risk category at ages 47·9 and 54·3 years respectively. When we used a broader definition of CVD that also included coronary or carotid revascularisation, the ages were 41·3 and 47·7 years for men and women with diabetes respectively.

Interpretation

Diabetes confers an equivalent risk to ageing 15 years. However, in general, younger people with diabetes (age 40 or younger) do not seem to be at high risk of CVD. Age should be taken into account in targeting of risk reduction in people with diabetes.

Affiliations
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Department of Medicine, St Michael's Hospital, Toronto, Ontario, Canada
Department of Medicine, University Health Network, Toronto, Ontario, Canada
Department of Medicine, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada
The University Health Network Women's Health Program, Toronto, Ontario, Canada
The Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada

(Juni 2006) 

 

 

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