Suikers
veroorzaken overgewicht en diabetes-2.*
Uit
een studie met ratten blijkt dat suikers zoals fructose in fruit en diverse
zoetstoffen veel toegepast in kant en klare voeding het lichaam voor de gek
houden waardoor een overdreven hongergevoel ontstaat. Verder kunnen de suikers
de urinezuur waarden in het bloed verhogen waardoor de werking van insuline
afgeremd wordt. De gevolgen zijn overgewicht
en op termijn diabetes type 2. Als bij de ratten het waarden urinezuur verlaagd
werden verloren ze gewicht, werd de insuline tolerantie en de bloeddruk minder.
Sugars
Might Speed Obesity
They may interfere with insulin to increase weight gain,
experts say
-- Fructose, the sugar found in fruit, honey and the
corn-syrup sweeteners
used in many processed foods, may trick the body into thinking it's hungrier
than it really is, researchers report.
The findings could explain why sweet foods help boost obesity
rates in the United States and elsewhere.
In their studies with rats, researchers at the
University of Florida identified fructose as part of a biochemical chain
reaction that causes weight gain and other characteristics of metabolic syndrome,
the precursor to Type 2 diabetes.
Fructose can also cause an increase of uric
acid
levels in the blood, the Florida team found. This temporary rise in uric acid
blocks the action of Insulin, the hormone that regulates how body cells
use and store the sugar they need for energy.
If increased uric acid levels occur frequently enough,
features of metabolic syndrome may develop over time, the researchers said.
These features include obesity, elevated blood cholesterol
levels and high blood
pressure.
The Florida researchers
fed rats a high-fructose diet for 10 weeks. All of the rats experienced an
increase in uric acid in the bloodstream and also went on to develop insulin
resistance.
"When we blocked or lowered uric acid, we were
able to largely prevent or reverse features of the metabolic syndrome," Dr.
Richard Johnson, professor of nephrology and chief of nephrology, hypertension
and transplantation at the university's College of Medicine, said in a prepared
statement. "We were able to significantly reduce weight gain, we were able
to significantly reduce the rise in the triglycerides in the blood, the [rats']
insulin resistance was less and the blood pressure fell."
The research appears in the December issue of the
journal Nature Clinical Practice Nephrology and in the online edition of
the American Journal of Physiology-Renal
Physiology.
