Veel groenten en fruit tegen mogelijke terugkeer borstkanker.*

In een studie werd gekeken of een gezond dieet de kans op terugkeer van borstkanker kan beïnvloeden. Daartoe werd het bloed van de deelnemers onderzocht op de aanwezigheid van verschillende carotenen, bioactieve stoffen die gevonden worden in groenten en fruit. Deze carotenen zijn een heel goede indicatie van de hoeveelheid groenten en fruit die dagelijks gegeten wordt. Het resultaat van de studie was dat vrouwen die de meeste carotenen in het bloed hadden de kans op terugkeer van borstkanker 43% lager was dan vrouwen met de laagste hoeveelheden carotenen.

Dus vrouwen die elke dag veel groenten en fruit eten hebben veel minder kans opnieuw borstkanker te krijgen.

Plasma Carotenoids and Recurrence-Free Survival in Women With a History of Breast Cancer

Cheryl L. Rock, Shirley W. Flatt, Loki Natarajan, Cynthia A. Thomson, Wayne A. Bardwell, Vicky A. Newman, Kathy A. Hollenbach, Lovell Jones, Bette J. Caan, John P. Pierce

From the Departments of Family and Preventive Medicine and Psychiatry, and Cancer Prevention and Control Program, University of California, San Diego, San Diego; and Division of Research, Kaiser Permanente Northern California, Oakland, CA; Arizona Cancer Center, University of Arizona, Tucson, AZ; M.D. Anderson Cancer Center, The University of Texas, Houston, TX; and the Women's Healthy Eating and Living Study Group

Address reprint requests to Cheryl L. Rock, PhD, RD, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093-0901; e-mail: clrock@ucsd.edu

PURPOSE: Previous studies suggest that diet may affect recurrence or survival rates in women who have been diagnosed with breast cancer. The purpose of this study was to examine the relationship between plasma carotenoid concentration, as a biomarker of vegetable and fruit intake, and risk for a new breast cancer event in a cohort of women with a history of early-stage breast cancer.

METHODS: Participants were 1,551 women previously treated for breast cancer who were randomly assigned to the control arm of a diet intervention trial between March 1995 and November 2000. Outcome events were probed during semiannual interviews and verified by medical record review. During the period under study, 205 women had a recurrence or new primary breast cancer. Plasma carotenoid concentrations were measured in baseline blood samples. Hazard ratios (HR) and 95% CIs by quartiles of plasma carotenoids were computed, controlling for tumor stage, grade, and hormone receptor status; chemotherapy and tamoxifen therapy; clinical site; age at diagnosis; body mass index; and plasma cholesterol concentration.

RESULTS: Women in the highest quartile of plasma total carotenoid concentration had significantly reduced risk for a new breast cancer event (HR, 0.57; 95% CI, 0.37 to 0.89), controlled for covariates influencing breast cancer prognosis.

CONCLUSION: Plasma carotenoids are a biologic marker of intake of vegetables and fruit, so this observation supports findings from previous studies that have linked increased vegetable and fruit intake with greater likelihood of recurrence-free survival in women who have been diagnosed with early-stage breast cancer.

Supported by NCI Grant No. CA69375; University of California, San Diego, General Clinical Research Center NIH Grant No. M01-RR00827; University of California, San Francisco, General Clinical Research Center NIH Grant No. M01-RR00079; Stanford University General Clinical Research Center NIH Grant No. M01-RR00070; and the Walton Family Foundation.

(December 2005) 

 

 

  

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