Wortelen (en andere groentes?) tegen kanker.*

Uit eerdere studies bleek dat het eten van wortelen de kans op kanker sterk doet verminderen nu is bij onderzoek (onder ratten) de stof gevonden de kans op kanker sterk doet verminderen. Het blijkt de stof te zijn die de wortel van nature beschermt tegen rotten, falcarinol. Alhoewel het hier een onderzoek met ratten betreft lijkt hier de vraag beantwoord te kunnen worden die in eerdere onderzoeken onbeantwoord bleef, wat veroorzaakt die daling in kans op kanker. Niet bekend is of wortelen rauw of gekookt hetzelfde resulaat geven. Wel is weer eens aangetoond dat het eten van groente de kans op kanker doet verlagen en niet extra vitamines omdat die ook bij dit onderzoek geen effect hadden. Vermoedelijk zullen ook in andere groentes dit soort stoffen aangetroffen worden die hetzelfde effect teweeg brengen als falcarinol in wortelen.

Crunch! Carrots May Cut Cancer Risk

Fungus-fighter in carrots cut tumors in rats by a third, researchers say.

-- There's more good news from the garden: A compound in carrots may be a potent cancer fighter, reducing malignancies in rats by a third, a European study claims.

"One of the natural pesticides in carrots is responsible for the cancer-preventing effect of carrots," said lead researcher Kirsten Brandt, a senior lecturer at the University of Newcastle upon Tyne, in England. "We now have identified a compound which seems to have an effect that can explain this benefit."

Nutrition experts have long recommended that people eat carrots because of their apparent ability to prevent cancer, but, until now, the particular compound driving this effect was not known. Epidemiological studies have shown that individuals with the highest carrot consumption can lower their risk of cancer by up to 40 percent.

Now, Brandt's team says that falcarinol, a compound that protects the vegetable from fungal diseases, may be the prime reason carrots are so unfriendly to cancers. One previous study had suggested that might be the case, but results were inconclusive.

To find out if falcarinol really does prevent cancer, Brandt's team studied 24 rats with precancerous tumors that mimicked human colorectal cancer. The rats were assigned to three groups, and each group was given a different diet.

After 18 weeks, Brandt's group found that rats that ate carrots along with their ordinary feed, as well as a second group that had falcarinol added to their feed, were one-third less likely to develop cancerous tumors compared with rats that were not given either, according to the report in the February issue of the Journal of Agricultural and Food Chemistry.

Brandt said the exact mechanism behind falcarinol's anti-cancer activity remains unknown. The researchers also don't know if the results seen in rats would be seen in humans. "But, it is encouraging that the data fits with what we have seen in humans," Brandt said.

These findings reinforce the message that people should eat five servings of fruit and vegetables everyday, she said.

"We have now tested carrots," she added. "But there are a lot of other vegetables that we have not tested, which might have the same properties. There are lots of other similar compounds in other vegetables."

However, whether the beneficial effect of falcarinol is diluted or eliminated when carrots are cooked or juiced is unknown. That needs to be tested, Brandt said.

The researchers were intrigued that the vegetable's natural pesticides may be the real cancer-fighters, not vitamins or other nutrients. According to Brandt, the discovery may answer the longstanding question, "Why is it that eating vegetables is so much better for your health than just taking a vitamin pill with the same amount of vitamins and minerals?"

In addition, the finding might be important in developing new cancer treatments, she said. However, Brandt believes the quickest benefit can be achieved by simply developing carrots that have more falcarinol. "We might be able to double the intake of falcarinol, and that might have large benefits for public health," she said. (Maart 2005)

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