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Relatie tussen koffiedrinken en vaatziektes.
Uit een onderzoek onder ruim 1500 mannen en evenveel vrouwen
blijkt dat het dat het drinken van meerdere koppen koffie per dag de kans op
vaatziektes flink doet toenemen.
Associations
between coffee consumption and inflammatory markers in healthy persons: the
ATTICA study1,2,3
Antonis
Zampelas, Demosthenes B Panagiotakos, Christos Pitsavos, Christina Chrysohoou
and Christodoulos Stefanadis
1
From the Department of Nutrition and Dietetics, Harokopio University, Athens,
Greece (AZ and DBP); and the First Cardiology Clinic, School of Medicine,
University of Athens, Greece (CP, CC, and CS).
Background:
The effect of coffee consumption on the cardiovascular system is
conflicting. Inflammation is important to the development of
cardiovascular disease (CVD), and several dietary factors are thought
to exert significant effects on inflammation and thus on the risk of
CVD.
Objective:
We aimed to investigate the associations between coffee consumption
and inflammatory markers.
Design:
The cross-sectional survey enrolled 1514 men (
± SD age: 46 ± 13 y; range: 18–87 y) and 1528 women (aged 45 ±
13 y; range: 18–89 y). Five percent of men and 3% of women were
excluded for history of CVD. Fasting blood samples were collected.
Dietary habits (including consumption of various types of coffee)
were evaluated by using a validated food-frequency questionnaire.
Results:
Compared with coffee nondrinkers, men who consumed >200 mL
coffee/d had 50% higher interleukin 6 (IL-6), 30% higher C-reactive
protein (CRP), 12% higher serum amyloid-A (SAA), and 28% higher tumor
necrosis factor
alfa(TNF-
alfa)
concentrations and 3% higher white blood cell (WBC) counts (all: P
< 0.05). Women who consumed >200 mL coffee/d had 54% higher
IL-6, 38% higher CRP, 28% higher SAA, and 28% higher TNF-alfa
concentrations and 4% higher WBC counts (all: P < 0.05)
than did coffee nondrinkers. The findings were significant even after
control for the interactions between coffee consumption and age, sex,
smoking, body mass index, physical activity status, and other covariates.
Conclusions:
A relation exists between moderate-to-high coffee consumption and
increased inflammation process. This relation could explain, in part,
the effect of increased coffee intake on the cardiovascular system.
American
Journal of Clinical Nutrition, Vol. 80, No. 4, 862-867, October 2004